Journal: BMJ Open

Article Title: Does the architectural layout of a NICU affect alarm pressure? A comparative clinical audit of a single-family room and an open bay area NICU using a retrospective study design

doi: 10.1136/bmjopen-2018-022813

Figure Lengend Snippet: Characteristics of neonatal intensive care units (NICUs) across several dimensions

Article Snippet: SpO 2 sensor , LNOP NeoPt-L or LNOP Neo, Masimo SET , M1132A, M1133A and M1134A, Philips.

Techniques:

Journal: Nature Communications

Article Title: A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

doi: 10.1038/s41467-024-48261-w

Figure Lengend Snippet: a Changes in blood oxygen saturation [SpO 2 , average value with 95% confidence interval (CI)] with acclimatization time. Hu sheep ( n = 10): 0 d, 97.30 (CI: 96.68 − 97.92); 7 d, 82.51 (CI: 81.87 − 83.15); 14 d, 83.67 (CI: 82.68 − 84.66); 21 d, 85.38 (CI: 84.24 − 86.52); 8 mon, 87.0 (CI: 86.03 − 87.97); and Tibetan sheep ( n = 10): 92.65 (CI: 91.68 − 93.62). Boxplots are represented by minima, 25% quantile, median, 75% quantile, and maxima with data points. b , c Changes in the nitric oxide synthetase (NOS) (b) and cardiac enzyme (CK) ( c ) values (average value with 95% CI) over time. In b , Hu sheep ( n = 10): 0 d, 7.05 µmol/L (CI: 6.69 − 7.41); 7 d, 5.71 µmol/L (CI: 5.17 − 6.25); 14 d, 5.23 µmol/L (CI: 5.03 − 5.43); 21 d, 5.78 µmol/L (CI: 5.33 − 6.23); 8 mon, 5.43 µmol/L (CI: 5.07 − 5.79); and Tibetan sheep ( n = 10), 6.40 µmol/L (CI: 5.88 − 6.92). In c , Hu sheep ( n = 10): 0 d, 62.1 U/L (CI: 48.64 − 75.56); 7 d, 60.0 U/L (CI: 40.45 − 79.55); 14 d, 64.2 U/L (CI: 56.87 − 71.53); 21 d, 55.2 U/L (CI: 44.64 − 65.76); 8 mon, 53.3 U/L (CI: 44.91 − 61.69); and Tibetan sheep ( n = 10), 146.7 U/L (CI: 69.15 − 224.25). P values in the figures a – c come from the two-sided Wilcoxon rank sum test. d t -distributed stochastic neighbor embedding ( t -SNE) clustering of 1277 RNA-Seq samples. e Association between gene modules and bio-indicators in blood. The rows represent the 14 gene modules (i.e., M1-M14), and the columns show 19 bio-indicators. Multiple testing was corrected using the Benjamini-Hochberg method. * FDR < 0.05. f Gene Ontology (GO) analysis for M3. g Gene examples in M3. Scatter plots show the Pearson’s correlation between the expression levels of genes and the values of bio-indicators over time. The two-sided P values are calculated by the linear regression model. Source Data are provided as Source Data file.

Article Snippet: Arterial SpO 2 was measured using the Tough/Ear Blood Oxygen Metre Veterinary SpO 2 PR Monitor (RocSea, Jingzhou, China) when the animals were stationary.

Techniques: RNA Sequencing Assay, Expressing

Journal: Nature Communications

Article Title: A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

doi: 10.1038/s41467-024-48261-w

Figure Lengend Snippet: a Changes in SpO 2 in the three lamb groups. The average values with 95% confidence interval (CI) of SpO 2 in lamb groups are: low-altitude Hu lamb ( n = 6), 91.50 (CI: 90.63 − 92.37); high-altitude Hu lamb ( n = 6), 85.92 (CI: 83.81 − 88.03); and Tibetan lamb ( n = 6), 97.71 (CI: 85.87 − 89.55). b Numbers of DEGs from the high-altitude Hu lamb vs. low- altitude Hu lamb (left) and Tibetan lamb vs. low-altitude Hu lamb comparisons (right). c Common GO terms enriched with the DEGs of low-altitude Hu lambs vs. high-altitude Hu lambs and low-altitude Hu lambs vs. Tibetan lambs in the kidney (top) and cerebrum (bottom). d GO terms enriched only with the DEGs from the low-altitude Hu lamb and high-altitude Hu lamb comparison in artery (top) and lung (bottom). e Expression levels of key genes from hypoxia response-related GO terms ( n = 6). expr, expression. Boxplots are represented by minima, 25% quantile, median, 75% quantile, and maxima. Each dot represents individual expression level in different groups. P values in the figures a and e come from the two-sided Wilcoxon rank sum test, “ns” indicates not significant. Source Data are provided as Source Data file.

Article Snippet: Arterial SpO 2 was measured using the Tough/Ear Blood Oxygen Metre Veterinary SpO 2 PR Monitor (RocSea, Jingzhou, China) when the animals were stationary.

Techniques: Comparison, Expressing